According to research published in the January issue of Clinical Gastroenterology and Hepatology, depressive symptoms are associated with a two-fold increase in risk of Crohn's disease (CD) but not ulcerative colitis (UC).
Ashwin N. Ananthakrishnan, M.B.B.S., M.P.H., of Massachusetts General Hospital and Harvard Medical School in Boston, & colleagues prospectively collected data from 152,461 women who participated in either the Nurses' Health Study I or II.
The authors wanted to determine whether there is a link between depressive symptoms & the incidence of Crohns and Ulcerative Colitis.
A total of 170 cases of CD and 203 cases of UC were reported while following this patient population. The researchers found that women with recent depressive symptoms, within the past four years, were 2.39-fold more likely to be diagnosed with CD. Women with depressive symptoms at baseline were 1.62-fold (95% confidence interval, 0.94 to 2.77) more likely to have CD. However, no association was found between either baseline or recent depressive symptoms and an increased risk of UC.
The authors writes, "We observed that depressive symptoms are associated with a two-fold increase in risk of CD but not UC. Although both within four years and remote (baseline) assessments of depression appear to influence disease risk, the association with recent depressive symptoms appeared more prominent. Our findings support the potential importance of a biopsychosocial model in the pathogenesis of CD and suggest the need for further studies on the effect of depression and stress on immune function and regulation."
5 April 2013