Metallothioneins (MTs) are exceptional candidate genes for Inflammatory Bowel Disease (IBD) and have formerly been shown to have altered expression in both human & animal studies of Inflammatory Bowel Disease.
This is the first study to examine genetic variants within the Metallothionein genes & aims to determine whether such genetic variants have an important role in this disease.
28 tag SNPs in genes MT1 (subtypes A, B, E, F, G, H, M, X), MT2, MT3 and MT4 were selected for genotyping in a well-characterized New Zealand dataset consisting of 406 patients with Crohn's Disease and 638 controls. No evidence was found in association to Metallothionein genetic variation with crohns disease.
The lack of association indicates that genetic variants in the MT genes do not play a significant role in predisposing to Crohns Disease in the New Zealand population.
31 January 2012