Here is the latest news from the Crohns and Colitis foundation "Under The microscope"... The connection between vitamin D and the normal immune system is gaining credibility. In IBD, there are numerous clues that suggest a role for vitamin D. Jon Burnham, M.D., of University of Pennsylvania, an expert in pediatric autoimmune disease, cautions that we need an expansion in research to draw conclusions about vitamin D in areas beyond skeletal health.
However, vitamin D is an intriguing field inviting more investigation. Martin Hewison, Ph.D., of UCLA/ Orthopedic Hospital presented animal experimental data. His data showed that vitamin D-deficient mice had significant increases in bacterial density in their gut. Dr. Hewison explained that vitamin D can affect the microbial community of the intestine, our microbiota, in multiple ways. He hypothesizes that vitamin D insufficiency may in fact be an environmental factor that contributes to IBD.
Researchers at Boston Children's Hospital under Helen Pappa, M.D., MPH, set up a study to provide physicians with better evidence-based guidance for treating vitamin D deficiency in pediatric cases of IBD. The results Dr. Pappa shared indicated that a high dose of the supplement, vitamin D3, 50,000 IU per week, was superior to other schemas in raising the blood level of vitamin D. Maintenance of blood levels of vitamin D is challenging. A regimen of 2,000 IU per day did, however, help to maintain a desirable level. An encouraging observation for future research was that maintenance of a desirable level of vitamin D correlated with lower levels of blood markers of inflammation in children with IBD.
See research by Helen Pappa
Under The Microscope
8 May 2012